Yes, you could use our Remo Drive Wipe to wipe any drives/partitions. Our software would wipe your drive without leaving any trace of your previous data. When you are wiping the OS drive, make sure that after wiping process, you would need to install your OS again. Also, wiping method may not complete properly as it will be processed from the same drive (which contains your computer OS) on which you are performing the Wiping method. So while wiping the OS drive we recommend to remove the drive from your computer and connect it to another working computer and perform the wiping on your OS drive.