Most of the applications on your Mac consist of two parts one for old PowerPC and one for new Intel version. You use only one part of the program and don't need another part; these are called "Binary Files". The program will run on either the old PowerPC architecture or the new Intel architecture. So, if you're an Intel Mac user, you've got all that space that's been included for PowerPC users which could be deleted.
Remo MORE has a unique feature called "Binary Cutter" which removes the un-needed program files, making your apps consume less hard drive space. Making the apps launch quicker.